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There was no impact on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see part 5.1). Sildenafil (100mg) didn’t affect the regular state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. These additional blood stress reductions were of a similar magnitude to those seen when sildenafil was administered alone to wholesome volunteers (see Part 5.1). Sildenafil (50mg) didn’t potentiate the hypotensive results of alcohol in healthy volunteers with imply maximum blood alcohol ranges of 80 mg/dl.
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